Effect of puerarin on glutamine synthetase activity in rat retina following acute intraocular hypertension

This study was conducted to demonstrate whether puerarin regulates glutamine synthetase (GS) activity following intraocular hypertension and has therapeutic potential in ophthalmology for the protection of optic nerves patients with glaucoma. used a Wistar rat model acute closed-angle glaucoma investigate effect on GS retina hypertension. Acute induced by increasing anterior chamber pressure 110 mmHg 30 min left eyes 50 rats, while 5 additional rats lacking were as control group. Retinal measured at 4, 12, 24, 36 72 h after induction with/without treatment. Compared group that lacked hypertension, significantly decreased 4 12 (P<0.01), before 24 restoring level similar h. However, (P<0.05) prevented loss seen h, no significant difference noted between treated these early time points. increased above values puerarin-treated eventually levels These findings suggest protects stages retinal may be benefit Key words: Puerarin, glutathione synthetase.